Nature Medicine

Print ISSN
1078-8956
Electronic ISSN
1546-170X
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25.43
Publisher
nature
URL
http://www.nature.com/nm/
Usage rank
70
Article count
7995
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734
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0.0918074
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CSA, Gale, Proquest, and Nature

  1. Inhibition of Fc epsilon RI-mediated mast cell responses by ES-62, a product of parasitic filarial nematodes.

    Nature Medicine 13(11):1375 (2007) PMID 17952092

    Atopic allergy is characterized by an increase in IgE antibodies that signal through the high-affinity Fcepsilon receptor (FcepsilonRI) to induce the release of inflammatory mediators from mast cells. For unknown reasons, the prevalence of allergic diseases has recently increased steeply in the ...
  2. Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1.

    Nature Medicine 13(11):1333 (2007) PMID 17982462

    Anorexia and weight loss are part of the wasting syndrome of late-stage cancer, are a major cause of morbidity and mortality in cancer, and are thought to be cytokine mediated. Macrophage inhibitory cytokine-1 (MIC-1) is produced by many cancers. Examination of sera from individuals with advance...
  3. Extralymphatic virus sanctuaries as a consequence of potent T-cell activation.

    Nature Medicine 13(11):1316 (2007) PMID 17982463

    T helper cells can support the functions of CD8(+) T cells against persistently infecting viruses such as murine lymphocytic choriomeningitis virus (LCMV), cytomegalovirus, hepatitis C virus and HIV. These viruses often resist complete elimination and remain detectable at sanctuary sites, such a...
  4. Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis.

    Nature Medicine 13(11):1349 (2007) PMID 17982464

    Data providing direct evidence for a causative link between endothelial dysfunction, microvascular disease and diabetic end-organ damage are scarce. Here we show that activated protein C (APC) formation, which is regulated by endothelial thrombomodulin, is reduced in diabetic mice and causally l...
  5. The long and short of it.
    Author(s) unavailable

    Nature Medicine 13(11):1265 (2007) PMID 17987005

    It can take twice as long to get a PhD in biomedical sciences in the US as it does in other countries such as the UK and Australia. Are US PhDs worth more, or are there advantages to a speedier system?
  6. New law gives FDA more influence to monitor drug safety.

    Nature Medicine 13(11):1269 (2007) PMID 17987008

  7. Blocking HDACs boosts regulatory T cells.

    Nature Medicine 13(11):1282 (2007) PMID 17987020

  8. Microarrays: retracing steps.

    Nature Medicine 13(11):1276 (2007) PMID 17987014

  9. STAT5A is epigenetically silenced by the tyrosine kinase NPM1-ALK and acts as a tumor suppressor by reciprocally inhibiting NPM1-ALK expression.

    Nature Medicine 13(11):1341 (2007) PMID 17922009

    Although STAT5A and STAT5B have some nonredundant functional properties, their distinct contributions to carcinogenesis are not clearly defined. Here we report that STAT5A expression is selectively inhibited by DNA methylation of the STAT5A gene promoter region in cells expressing the oncogenic ...
  10. Researchers look for 'sweet' method to diagnose cancer.

    Nature Medicine 13(11):1267 (2007) PMID 17987006

  11. Program targets undergrads to make an early start on science.

    Nature Medicine 13(11):1268 (2007) PMID 17987007

  12. Reply to 'Poor trial design leaves gene therapy death a mystery'.

    Nature Medicine 13(11):1276 (2007) PMID 17987015

  13. Deacetylase inhibition promotes the generation and function of regulatory T cells.

    Nature Medicine 13(11):1299 (2007) PMID 17922010

    Histone/protein deacetylases (HDACs) regulate chromatin remodeling and gene expression as well as the functions of more than 50 transcription factors and nonhistone proteins. We found that administration of an HDAC inhibitor (HDACi) in vivo increased Foxp3 gene expression, as well as the product...
  14. Straight talk from... Victoria Hale.

    Nature Medicine 13(11):1274 (2007) PMID 17987011

  15. APC and colon cancer: two hits for one.

    Nature Medicine 13(11):1286 (2007) PMID 17987022

  16. Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins.

    Nature Medicine 13(11):1359 (2007) PMID 17934472

    A molecular test for Alzheimer's disease could lead to better treatment and therapies. We found 18 signaling proteins in blood plasma that can be used to classify blinded samples from Alzheimer's and control subjects with close to 90% accuracy and to identify patients who had mild cognitive impa...
  17. Deacetylase inhibition promotes the generation and function of regulatory T cells.

    Nature Medicine 13(11):1299 (2007) PMID 17922010

    Histone/protein deacetylases (HDACs) regulate chromatin remodeling and gene expression as well as the functions of more than 50 transcription factors and nonhistone proteins. We found that administration of an HDAC inhibitor (HDACi) in vivo increased Foxp3 gene expression, as well as the product...
  18. CD16 promotes Escherichia coli sepsis through an FcR gamma inhibitory pathway that prevents phagocytosis and facilitates inflammation.

    Nature Medicine 13(11):1368 (2007) PMID 17934470

    Sepsis, a leading cause of death worldwide, involves proinflammatory responses and inefficient bacterial clearance. Phagocytic cells play a crucial part in the prevention of sepsis by clearing bacteria through host innate receptors. Here we show that the FcRgamma adaptor, an immunoreceptor tyros...
  19. A MSC-ing link in metastasis?

    Nature Medicine 13(11):1289 (2007) PMID 17987025 PMCID PMC2267025

  20. Reply to 'Poor trial design leaves gene therapy death a mystery'.

    Nature Medicine 13(11):1276 (2007) PMID 17987015