The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models.
Nature 538(7626):477 (2016)
Avoidance of apoptosis is critical for the development and sustained growth of tumours. The pro-survival protein myeloid cell leukemia 1 (MCL1) is overexpressed in many cancers, but the development of small molecules targeting this protein that are amenable for clinical testing has been challengi...
The antibody aducanumab reduces A? plaques in Alzheimer's disease.
Nature 537(7618):50 (2016)
Alzheimer's disease (AD) is characterized by deposition of amyloid-_ (A_) plaques and neurofibrillary tangles in the brain, accompanied by synaptic dysfunction and neurodegeneration. Antibody-based immunotherapy against A_ to trigger its clearance or mitigate its neurotoxicity has so far been uns...
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.
Nature 450(7170):712 (2007)
Calorie restriction extends lifespan and produces a metabolic profile desirable for treating diseases of ageing such as type 2 diabetes. SIRT1, an NAD+-dependent deacetylase, is a principal modulator of pathways downstream of calorie restriction that produce beneficial effects on glucose homeosta...
Hes1 is a target of microRNA-23 during retinoic-acid-induced neuronal differentiation of NT2 cells.
Nature 423(6942):838 (2003)
MicroRNAs (miRNAs) are phylogenetically widespread small RNAs of 18-25 nucleotides in length, and are found in animals and plants. These small RNAs can regulate gene expression at a translational level through interactions with their target messenger RNAs, and they have a role in the development...
US army attacked over published patent for 'bioweapons grenade'.
Nature 423(6942):789 (2003)
A very energetic supernova associated with the gamma-ray burst of 29 March 2003.
Nature 423(6942):847 (2003)
Over the past five years evidence has mounted that long-duration (>2 s) gamma-ray bursts (GRBs)-the most luminous of all astronomical explosions-signal the collapse of massive stars in our Universe. This evidence was originally based on the probable association of one unusual GRB with a supernov...
Sea-level fluctuations during the last glacial cycle.
Nature 423(6942):853 (2003)
The last glacial cycle was characterized by substantial millennial-scale climate fluctuations, but the extent of any associated changes in global sea level (or, equivalently, ice volume) remains elusive. Highstands of sea level can be reconstructed from dated fossil coral reef terraces, and thes...
Automatic gain control in the echolocation system of dolphins.
Nature 423(6942):861 (2003)
In bats and technological sonars, the gain of the receiver is progressively increased with time after the transmission of a signal to compensate for acoustic propagation loss. The current understanding of dolphin echolocation indicates that automatic gain control is not a part of their sonar sys...
Producing decaffeinated coffee plants.
Nature 423(6942):823 (2003)
Nature 423(6942):796 (2003)
Beating the superparamagnetic limit with exchange bias.
Nature 423(6942):850 (2003)
Interest in magnetic nanoparticles has increased in the past few years by virtue of their potential for applications in fields such as ultrahigh-density recording and medicine. Most applications rely on the magnetic order of the nanoparticles being stable with time. However, with decreasing part...
Fibronectin requirement in branching morphogenesis.
Nature 423(6942):876 (2003)
Many organs, including salivary glands, lung and kidney, are formed during embryonic development by epithelial branching. In branching morphogenesis, repetitive epithelial cleft and bud formation create the complex three-dimensional branching structures characteristic of many organs. Although th...
Abundant gene conversion between arms of palindromes in human and ape Y chromosomes.
Nature 423(6942):873 (2003)
Eight palindromes comprise one-quarter of the euchromatic DNA of the male-specific region of the human Y chromosome, the MSY. They contain many testis-specific genes and typically exhibit 99.97% intra-palindromic (arm-to-arm) sequence identity. This high degree of identity could be interpreted a...
Involvement of Notch and Delta genes in spider segmentation.
Nature 423(6942):863 (2003)
It is currently debated whether segmentation in different animal phyla has a common origin and shares a common genetic mechanism. The apparent use of different genetic networks in arthropods and vertebrates has become a strong argument against a common origin of segmentation. Our knowledge of ar...
The missing link in Ginkgo evolution.
Nature 423(6942):821 (2003)
Tales of the Y chromosome.
Nature 423(6942):810 (2003)
Britannica: which edition inspired Schwinger?
Nature 423(6942):801 (2003)
The crystal's in the mail...
Nature 423(6942):799 (2003)
Rings of excitement.
Nature 423(6942):818 (2003)
Traditional wheat breeder fights for funding.
Nature 423(6942):790 (2003)