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- Springer from 1901, Ebsco from 1901 to 2009, Ovid from 2003, Ingenta from 1997 to 2004, Metapress from 1970, and Sciencedirect from 1970 to 1994
Correlated behavioral traits in rats of the Roman selection lines.
We hypothesized that RHA rats would show high levels of offensive behavior and are more impulsive compared to RLA rats. We characterized animals in a two-way active avoidance task on five consecutive days. Thereafter animals were tested for their level of offensive aggression and impulsive behavior....
The use of imputed sibling genotypes in sibship-based association analysis: on modeling alternatives, power and model misspecification.
We compared the performance of two statistical approaches suitable to model imputed genotype data: the mixture approach, which involves the full distribution of the imputed genotypes and the dosage approach, where the mean of the conditional distribution features as the imputed genotype. Simulations...
Stable genetic effects on symptoms of alcohol abuse and dependence from adolescence into early adulthood.
We examined the change in influence of genetic and environmental factors which explain symptoms of AAD from adolescence into early adulthood. Symptoms of AAD were assessed using the four AAD screening questions of the CAGE inventory. Data were obtained up to six times by self-report questionnaires f...
Untreated hypertension decreases heritability of cognition in late middle age.
We examined whether hypertension modifies genetic influences on individual differences in cognition. Nine cognitive domains and general cognitive ability were assessed in a sample of 1,237 male twins aged 51-60 who were divided into three blood pressure groups: non-hypertensive; medicated hypertensi...
Heritability across the distribution: an application of quantile regression.
We introduce a new method for analyzing twin data called quantile regression. Through the application presented here, quantile regression is able to assess the genetic and environmental etiology of any skill or ability, at multiple points in the distribution of that skill or ability. This method is...
Genetic covariation underlying reading, language and related measures in a sample selected for specific language impairment.
Specific language impairment is a developmental language disorder characterized by failure to develop language normally in the absence of a specific cause. Previous twin studies have documented the heritability of reading and language measures as well as the genetic correlation between those measure...
A simple bias correction in linear regression for quantitative trait association under two-tail extreme selection.
Selective genotyping can increase power in quantitative trait association. One example of selective genotyping is two-tail extreme selection, but simple linear regression analysis gives a biased genetic effect estimate. Here, we present a simple correction for the bias.
Food neophobia in young adults: genetic architecture and relation to personality, pleasantness and use frequency of foods, and body mass ind...
We studied genetic and environmental effects on variation in food neophobia, measured using the Food Neophobia Scale, and explored associations between food neophobia and personality, pleasantness and use frequency of food groups, and body mass index in young adult twins (N = 1175, aged 20-25 years,...
Selective breeding for increased home cage physical activity in collaborative cross and Hsd:ICR mice.
We conclude that different genes and neural circuits influence physical activity in the home cage as compared to wheel running or open field. Selective breeding for home cage activity in CC mice warrants further exploration....
Using non-normal SEM to resolve the ACDE model in the classical twin design.
One of the biggest problems in classical twin studies is that it cannot estimate additive genetic (A), non-additive genetic (D), shared environmental (C), and non-shared environmental (E) effects, simultaneously, because the model, referred to as the ACDE model, has negative degrees of freedom when...